Research project/ Research Group description: The main focus of our laboratory is to study cellular and molecular mechanisms involved in the morphogenesis of the vertebrate eye. Using the teleost models zebrafish and medaka, we investigate the machinery driving the folding of the retinal neuroepithelium. Optic cup morphogenesis is an atypical model for epithelial morphogenesis for, in contrast to well-known apical constrictions, it involves the folding of the tissue towards its basal surface. Although it is generally accepted that optic cup formation follows a tissue-intrinsic program in vertebrates, several mechanisms have been postulated (basal constriction, rim involution) and some important differences in cell behaviour have been reported among species. Many important questions still remain open. Which is the relative contribution of each mechanism to the folding of the optic cup? Do they act in a cooperative manner? Do they have the same regulatory weight in different species? To answer these questions, we aim to integrate genetic information, imaging analysis of cell shape changes, and tensional forces distribution into coherent computational models able to predict the key morphogenetic rules that shape the entire organ. We plan to extend our observations to mammalian tissue, by examining cell shape changes and tensions in 3D retinal organoids developed in vitro. A key aspect of the project is to understand how classical signalling events, which have proved to be essential for the proper patterning of the organ, act in coordination with tensional forces. This highly interdisciplinary approach, combining genetics, imaging, biophysics and computational modelling should yield information relevant not only to understand optic cup formation, but also to deduce general self-organization principles of the living matter.
Last Publications: Letelier et al. (2018a) Nat Genetics, Letelier et al (2018b) PNAS, Nicolás-Pérez et al (2016). eLife; Gago-Rodrigues et al (2015). Nat Comm ; Tena et al (2014) Genome Research; Bogdanovic et al (2012). Developmental Cell. 23 (4). For a full list: https://www.ncbi.nlm.nih.gov/pubmed/?term=Martinez-morales+JR
Job position description: We offer a one-year renewable contract and full support to apply for external funding. Given the interdisciplinary character of the project above described, we are seeking talented and highly motivated postdoctoral researchers with a background either in Developmental Biology or in Biophysics. Previous experience with teleost models will be well received. The candidates should have good communication skills, critical for ensuring the success of the team effort. We offer an adequate environment to mature scientifically and eventually to become independent scientists. The CABD is thematically focused on the topic of Cellular and Developmental Biology, and is well equipped in terms of infrastructure, particularly for imaging analyses. Our research unit, the department of Gene Regulation and Morphogenesis was recently awarded with the María de Maeztu distinction of excellence. A series of external seminars by prominent Spanish and international speakers are organized on a weekly basis. In addition, a biweekly series of seminars allow PhD students and postdoctorals to present their work. English is the official language in the CABD as well as in our internal seminars, as international researchers are frequent visitors/members in our group.
Contact information: Juan R. Martínez-Morales. Gene regulation and Morphogenesis Department CABD. (CSIC/UPO). Seville, Spain. Email: firstname.lastname@example.org
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POSTDOCTORAL POSITION is immediately available to study different aspects of lymphatic vasculature development using a variety of available mouse models. Highly motivated individuals who recently obtained a PhD. or MD degree and have a strong background in mammalian vascular, molecular and developmental biology are encouraged to apply.
Interested individuals should send their curriculum vitae, a brief description of their research interests, and the names of three references to: Guillermo Oliver, Ph.D.
Thomas D Spies Professor of Lymphatic Metabolism. Director Center for Vascular and Developmental Biology Northwestern University Feinberg School of Medicine. 303 East Superior Street,10-107. Chicago, Illinois 60611
A postdoctoral position is available in the Sokol laboratory in the Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York. Our group uses live imaging, genome editing and proximity biotinylation approaches to assess cell signaling and lineage decisions during gastrulation and neural development. We also interested in the roles of the centrosome and cilia in epithelial cell polarity and asymmetric cell divisions in Xenopus, zebrafish and mammalian progenitor cells. See the description of our interests at (http://labs.icahn.mssm.edu/sokollab/ or http://icahn.mssm.edu/profiles/sergei-y-sokol)
Preference will be given to motivated applicants with strong background in cell biology, bioinformatics and biochemistry, who published a first-author paper as a result of their graduate work. Interested candidates may send their CV, list of publications and three references to Dr. Sergei Sokol (email@example.com)
Programas Especiales: Intercambio académico, Biomedicina y Salud, Transferencia tecnológica. Herramientas bioinformáticas. Uso de animales transgénicos. Beneficios del Programa: Becas de Arancel y Contrato de Planta. Becas de apoyo pasantías externas.
Lineas de Investigación: Desarrollo del Sistema Nervioso. Fisiología del Sistema Nervioso y Periférico. Enfermedades Neuro degenerativas. Fisiología del sistema nervioso en modelos animales. Mecanismos celulares y moleculares. Desarrollo de terapia génica y farmacológicas. Neurobiología traslacional y Neuroinmunología. Análisis masivo de datos (genómica, proteómica, metabolómica). Aspectos moleculares del envejecimiento. Metabolismo neuronal.
The project is focused on the implication of neural crest9derived meninges in brain homeostasis. It aims at understanding how the cephalic neural crest (CNC), a multipotent structure, which provides the developing forebrain with meninges and a functional microvasculature, exerts a deterministic role in the biology and physiology of choroid plexus, and regulates the production of cerebro9spinal fluid. More specifically, our project aims at understanding how the dysfunctions of CNC cells, and the meninges they form, could affect the development of the intracerebral vascular network and eventually cause neurodevelopmental defects.
Highly qualified and motivated candidate, who have completed a PhD in Developmental Biology or in Neurosciences, and with the following research skills are encouraged to apply: strong background in molecular and cellular developmental biology; good knowledge in neurobiology of cognitive functions experience in microsurgical manipulations of embryonic tissues, cell cultures ; immunocyto and histochemistry; imaging (acquisition and treatment) ; English (written and spoken) Team working skills; Organizational skills and motivation; Autonomy in project management The position is funded for 18 months by the Foundation for Medical Research (FRM); expected starting in January 2018. Applications will be considered until mid November 2017 if the position is not yet filled. Please send a CV, three references, and a motivation letter to: firstname.lastname@example.org
The Meyer lab at Clark University (http://wordpress.clarku.edu/nmeyer/) seeks a postdoctoral research fellow to investigate the molecular control of neural fate specification in annelids. Successful candidates will have expertise in developmental biology, evo-devo, and molecular biology. Experience working with marine organisms, microinjection, CRISPR/Cas9, transcriptomic data, and/or statistical analyses also is desirable but not required. Additionally, the Meyer lab is interested in candidates who can contribute to diversity of the academic community through development of outreach programs for the local community or that have experience in mentoring students from historically underrepresented communities.
Applicants should submit a cover letter explaining your interest in the position and qualifications, a curriculum vitae, a statement of research interests, two key publications, and contact information for three references in one electronic file by email to Dr. Néva Meyer (email@example.com). Further information is available by contacting Dr. Meyer by email or phone (508-793-7476). Review of applications will begin immediately and will continue until the position is filled, but candidates able to start on or before January 15, 2018 will be given preference. This is a three-year position with the possibility of extension pending funding.
The positions are highly competitive and the application process has two phases. In the first round the students should apply to the program, and in the second, those selected will be allowed to chose lab, one being offered by Gene regulation and morphogenesis lab, James Castelli-Gair Hombría PI. Email enquiries to: firstname.lastname@example.org. See also: https://obrasociallacaixa.org/el/educacion-becas/becas-de-posgrado/inphinit/programme-description and http://www.cabd.es/en-research_groups-11-21-cell-integration-of-diverse-genetic-inputs-during-the-morphogenesis-of-complex-organs-summary.html
Organs evolve to perform their functions more efficiently, allowing organisms to adapt to changing environments and to explore new niches. Despite the acceptance of these premises, there are no models to analyse how these adaptations happened. Taking advantage of the deep knowledge our laboratory has on the cellular and molecular processes controlling the organogenesis of the endocrine glands and the respiratory organs of Drosophila, we will study how organogenesis evolved in related species. For this purpose we will analyse species with defined organ differences and study how the differential regulation of genes controlling Drosophila organogenesis has varied between species to give rise to new shapes and organ associations while maintaining the basic function. We will take advantage of advances in genome sequencing and novel genetic tools like Crispr that allow probing the function of homologous genes in non model organisms. Arthropods have occupied all niches on earth and have some of the most successful groups. This has been achieved through the development of segment specific organs that specialized as different species occupied novel environments, as exemplified by the four times aquatic Arthropods adapted to terrestrial life. This resulted in a number of organs that, evolving from preexisting ones, have adapted their organogenetic networks to perform their function in different environments. Drosophila has become one of the best models to study from the cellular and molecular point of view how organogenesis unfolds and this is the ideal starting point to understand how related species may have modified pre-existing organogenetic gene networks for adaptation. Our laboratory has uncovered how the external respiratory organs and the main endocrine organs develop. We propose to use comparative organogenesis of these organs to analyse how organ evolution occurred through medium and large evolutionary distances.
The López-Schier laboratory at the Helmholtz Zentrum Munich in Germany is seeking creative and highly motivated PhD students or postdoctoral scholars to work within our group.
We currently have 4 fully funded openings for the following projects: 1. Cellular and genetic bases of organ formation, including cell packing and tissue remodelling. We single-cell transcriptional profiling, genome engineering using CRISPR/Cas9 and quantitative live imaging data using light-sheet microscopy. Preference will be given to candidates with theoretical or practical knowledge in cell biology or biophysics. 2. Control of cell number and diversity in sensory organs. Candidates should have a strong theoretical background in cell biology, and a good command of computer programming. 3. Stem cells and organ regeneration, including organ size and proportions. We use state of the art optical imaging, optogenetics and genome engineering to unravel what triggers the regenerative response after tissue injury. This project is ideal for a candidate with studies in biology, informatics, or with experience in computer programming. 4. Stem cells and organ pattern formation, including cell packing. Using high-resolution cellular tracking and machine learning, we attempt to understand how cells self-organize during organ repair and to predict cellular behavior. This project is ideal for a candidate with studies in informatics, mathematics, or experience in machine learning.
The Laboratory for Genetic Control of Neuronal Architecture (Moore; RIKEN Brain Science Institute, Tokyo, Japan) is recruiting a skilled molecular biologist. The candidate will develop novel single cell profiling technologies, and apply them to study neuronal development. Additional neuronal development studies will also be carried out. The single cell profiling technology development part of this project will be carried out in close collaboration with the Genomics Miniaturization Technology Unit (Plessy; RIKEN Center for Life Science Technologies, Yokohama, Japan).
A demonstrated record of technical and intellectual molecular biology excellence is the primary criterion for this position. The candidate is expected to play a leading role in a collaborative team, and a proven ability to function effectively in a team will be also considered in the selection process. Interested postdoctoral researchers are encouraged to send an email containing 1) a curriculum vitae including publications and names of three references, 2) a short description of skills and experience to Adrian Moore (email@example.com). Working level English is required. Japanese language skills are not a requirement.
Fully funded postdoctoral positions are presently available in the Conlon Lab whose studies focus on identifying the molecular networks that are essential for early heart development and how alterations in these networks lead to congenital heart disease. For these studies, we use a highly integrated approach that incorporates developmental, genetic, proteomic, biochemical and molecular based studies in mouse, Xenopus and stem cells. Recent advances and projects of interest in the Conlon lab include studies that define the cellular and molecular events that lead to cardiac septation, those that explore cardiac interaction networks as determinants of transcriptional specificity, the mechanism and function of cardiac transcriptional repression networks and, the regulatory networks of cardiac morphogenesis.
Job Requirements: Candidates should have recently obtained or be about to obtain a Ph.D. or M.D. in a field of biological science and should have a strong publication record. Outstanding and highly motivated candidates should apply by email to Dr. Frank L. Conlon and include a CV/resume, three references and description of your specific interest in our research programs.
Primary responsibilities will include an undergraduate teaching load of 12 contact hours per semester. The candidate is expected to teach introductory biology for majors, an upper division course in developmental biology, and other courses as needed. Secondarily, the candidate is expected to engage in scholarly and research activity that involves undergraduates, advise students, and provide service to the department, college, university and broader community. Research activities must yield peer-reviewed publications. PhD preferred (advanced ABD candidates considered), prior teaching and research experience with undergraduates is desirable. Salary for this position is competitive and commensurate with experience. Review of applications will begin November 1, 2017, and continue until the position is filled. Limited start-up packages and modest research space are available for tenure-track positions.
Three year Wellcome funded postdoc position available in the Srinivas lab in the University of Oxford, to investigate patterning in the early post-implantation mouse embryo. We are looking for someone who is enthusiastic about using multi-disciplinary approaches including fluorescent reporters, advanced imaging and single cell sequencing to study the molecular mechanisms controlling early embryonic patterning.
Apply online before 25th September, 2017 http://tinyurl.com/ssLab-postdoc Email informal enquiries to: firstname.lastname@example.org.
The Biology Department at Southern Connecticut State University invites applicants for a full-time, tenure-track position in Invertebrate Developmental Biology at the Assistant Professor level. We seek candidates that will offer general biology courses for non-majors and majors and courses in developmental biology for undergraduate and graduate students, as well as courses that support the B.S. program in Biotechnology. The Biology Department offers the B.S. and B.A. degrees in Biology, the B.S. degree in Biology with teacher-certification (7-12), the B.S. degree in Biotechnology, the M.S. in Biology, and a post-baccalaureate program for initial teacher certification. Please see our website at http://www.southernct.edu/biology for more information.
Brief Description of Duties/Responsibilities: Candidates must be committed to teaching within a vibrant and demanding public liberal arts and sciences environment. Tenure-track faculty at SCSU are expected to conduct research/creative activity in their area of expertise. Creative activities include mentoring student research leading to publication of theses, publishing articles in academic and professional journals, seeking funding in support of research and teaching needs, and contributing to workshops and conferences.
Required Qualifications: Candidates must have earned a Ph.D. by the time of appointment in developmental biology or a related field and possess experience teaching at the university level.
Application Process: Please send electronically a cover letter, curriculum vitae, statement of research interests and plans, statement of teaching philosophy and interests, three letters of recommendation, representative reprints, teaching evaluations, and any other evidence of teaching effectiveness to: Biology Search Committee Chair at BIOsearch1@southernct.edu. Please include your personal contact information along with a work address on your CV. In order for your application to be given full consideration, all materials must be received by Monday, October 16, 2017. The position will remain open until filled.
Please submit your letter of interest, updated CV, and contact information of three references to Federico Brown (email@example.com) http://zoologia.ib.usp.br/evodevo2/
Para trabajar en “Función de Lin28 y la hormona tiroidea en el desarrollo perinatal de ratón”. Los interesados dirigir CURRICULUM VITAE y PUBLICACIONES a: Juan Larraín firstname.lastname@example.org
P. Universidad Católica de Chile. Laboratorio de Biología del Desarrollo y Regeneración. Facultad de Ciencias Biológicas
VISUAL-D, a recently formed research initiative funded by the Chilean government for the visualisation and manipulation of signal and forces in developing tissues, is seeking proactive candidates with experience in developmental biology and/or morphogenesis, ideally (but not required) in zebrafish, willing to create new projects that associate developmental biology/morphogenesis with mathematics/computing/physics in a trans disciplinary scientific environment. Applicants must be about to finish or have a Ph.D. (awarded within the last 4 years) and a demonstrated track record of publications. To apply, applicants should send a full CV and a short statement of research interests to Prof. Miguel Concha (email@example.com) by July 1st 2016.For more information, please download the pdf file (https://www.dropbox.com/s/az4m2x7lubg2r0g/Postdoc%20anouncement_VisualD%2016May2016.pdf?dl=0)